Sports Nutrition

IgG Plus® provides Essential Sports Nutrition

IgG Plus® brings more than a new natural protein source to the market. In general, the immune system is suppressed by intensive training, with many factors being reduced or disturbed during the hours following a workout. This places athletes at an increased risk of succumbing to an infectious illness during this time.

Sports Nutrition

IgG Plus® provides Essential Sports Nutrition

IgG Plus® brings more than a new natural protein source to the market. In general, the immune system is suppressed by intensive training, with many factors being reduced or disturbed during the hours following a workout. This places athletes at an increased risk of succumbing to an infectious illness during this time.

Supports Intestinal Health

A wealth of data from research studies demonstrates that oral administration of SBI supports intestinal health and nutrient absorption. High immunoglobulin-containing serum protein preparations such as SBI have been shown to consistently improve the growth, food intake and other nutritional parameters in a variety of animal species (40). Torrallardona (41) summarized the results from over 70 animal studies and showed that immunoglobulin-containing plasma protein preparations, like SBI, were safe and supported caloric intake, growth and metabolism, and utilization of nutrients following supplementation in healthy animals. Collectively, such reports have led to the extensive use of plasma protein isolates as an animal feed component since the 1980’s in order to support feed intake, nutrient utilization, and

Supports Intestinal Health

A wealth of data from research studies demonstrates that oral administration of SBI supports intestinal health and nutrient absorption. High immunoglobulin-containing serum protein preparations such as SBI have been shown to consistently improve the growth, food intake and other nutritional parameters in a variety of animal species (40). Torrallardona (41) summarized the results from over 70 animal studies and showed that immunoglobulin-containing plasma protein preparations, like SBI, were safe and supported caloric intake, growth and metabolism, and utilization of nutrients following supplementation in healthy animals. Collectively, such reports have led to the extensive use of plasma protein isolates as an animal feed component since the 1980’s in order to support feed intake, nutrient utilization, and

Maintains Immune Function

The impact of SBI on immune function has also been evaluated in human clinical trials. In an early open-label study of SBI patients, SBI supplementation led to significant improvements in symptom and quality-of-life measures and increases in CD4+ counts in the duodenum (46). In a large multicenter, placebo-controlled follow-up study (47), SBI administration led to significant increases in peripheral CD4+ cells at week 4 and week 24 among subjects in the lowest quartile for baseline CD4+ cells (<418 cells/mL), when compared to subjects that received placebo. Levels of CD4+ cells and CD4+/CD8+ cell ratios were also increased in duodenal mucosal biopsies. The study also found significant decreases in circulating levels of interleukin-6 (a proinflammatory cytokine) and markers of intestinal barrier damage and enterocyte death. Authors concluded that the results support the hypothesis that binding and exclusion of gut bacterial antigens by SBI helps to support the mucosal and systemic immune functions.

Maintains Immune Function

The impact of SBI on immune function has also been evaluated in human clinical trials. In an early open-label study of SBI patients, SBI supplementation led to significant improvements in symptom and quality-of-life measures and increases in CD4+ counts in the duodenum (46). In a large multicenter, placebo-controlled follow-up study (47), SBI administration led to significant increases in peripheral CD4+ cells at week 4 and week 24 among subjects in the lowest quartile for baseline CD4+ cells (<418 cells/mL), when compared to subjects that received placebo. Levels of CD4+ cells and CD4+/CD8+ cell ratios were also increased in duodenal mucosal biopsies. The study also found significant decreases in circulating levels of interleukin-6 (a proinflammatory cytokine) and markers of intestinal barrier damage and enterocyte death. Authors concluded that the results support the hypothesis that binding and exclusion of gut bacterial antigens by SBI helps to support the mucosal and systemic immune functions.

FEATURES & BENEFITS OF IgG Plus®

  • Helps restore a healthy immune system that has been compromised by external stresses
  • A source of key peptides that may support health and recovery from intensive exercise sessions
  • Provides important immunoglobulins and other proteins to avoid immune-depressive effects of strenuous and prolonged exercise
  • Safety and immune benefits documented in human clinical trials
  • Sourced from all natural and high-quality materials
  • Proprietary process that preserves the quality of active immunoglobulins and other proteins
  • Non-allergenic protein source

After clicking the buy now button you will be redirected to our affiliate site carlo pacific to complete your purchase.

FEATURES & BENEFITS OF IgG Plus®

  • Helps restore a healthy immune system that has been compromised by external stresses
  • A source of key peptides that may support health and recovery from intensive exercise sessions
  • Provides important immunoglobulins and other proteins to avoid immune-depressive effects of strenuous and prolonged exercise
  • Safety and immune benefits documented in human clinical trials
  • Sourced from all natural and high-quality materials
  • Proprietary process that preserves the quality of active immunoglobulins and other proteins
  • Non-allergenic protein source

After clicking the buy now button you will be redirected to our affiliate site carlo pacific to complete your purchase.

Other Features That May Benefit Exercise Performance

Previous studies used a mouse model of acute lung injury to show that plasma or immunoglobulin concentrates can improve the inflammatory cytokine profile and reduce the percentage of activated neutrophils and monocytes in lung airway and lung tissue (52, 53). While these results may be surprising to some, it is widely recognized that the mucosal immune systems associated with different tissues are highly interconnected. Which means that stimulation of the intestinal immune system can modulate the local immune response, which in turn may modify the immune response of other mucosal (i.e. respiratory) lymphoid tissues (54). Furthermore, oral immunoglobulin may also help support respiratory epithelia following extreme exercise – as well as replace the loss of salivary immunoglobulins to help avoid respiratory infections (16, 17). These results using the acute lung injury model may be important and relevant for sports nutrition products, since it implies that oral immunoglobulin concentrates like SBI may help support the bodies response beyond the GI tract.

Other Features That May Benefit Exercise Performance

Previous studies used a mouse model of acute lung injury to show that plasma or immunoglobulin concentrates can improve the inflammatory cytokine profile and reduce the percentage of activated neutrophils and monocytes in lung airway and lung tissue (52, 53). While these results may be surprising to some, it is widely recognized that the mucosal immune systems associated with different tissues are highly interconnected. Which means that stimulation of the intestinal immune system can modulate the local immune response, which in turn may modify the immune response of other mucosal (i.e. respiratory) lymphoid tissues (54). Furthermore, oral immunoglobulin may also help support respiratory epithelia following extreme exercise – as well as replace the loss of salivary immunoglobulins to help avoid respiratory infections (16, 17). These results using the acute lung injury model may be important and relevant for sports nutrition products, since it implies that oral immunoglobulin concentrates like SBI may help support the bodies response beyond the GI tract.

    If you do not experience a significant improvement in the way Extreme Immunity makes you feel, return it within 30 days for a full refund less Shipping & Handling. No questions asked!

    REFERENCES
    1. Rennie MJ, Wackerhage H, Spangenburg EE, Booth FW. Control of the size of the human muscle mass. Annual review of physiology. 2004;66:799-828.

    2. Biolo G, Tipton KD, Klein S, Wolfe RR. An abundant supply of amino acids enhances the metabolic effect of exercise on muscle protein. The American journal of physiology. 1997;273(1 Pt 1):E122-9.

    3. Moore DR, Robinson MJ, Fry JL, Tang JE, Glover EI, Wilkinson SB, et al. Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men. The American journal of clinical nutrition. 2009;89(1):161-8.

    4. Tang JE, Manolakos JJ, Kujbida GW, Lysecki PJ, Moore DR, Phillips SM. Minimal whey protein with carbohydrate stimulates muscle protein synthesis following resistance exercise in trained young men. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme. 2007;32(6):1132-8.

    5. Moore DR, Phillips SM, Babraj JA, Smith K, Rennie MJ. Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions. American journal of physiology Endocrinology and metabolism. 2005;288(6):E1153-9.

    6. Tang JE, Moore DR, Kujbida GW, Tarnopolsky MA, Phillips SM. Ingestion of whey hydrolysate, casein, or soy protein isolate: effects on mixed muscle protein synthesis at rest and following resistance exercise in young men. Journal of applied physiology. 2009;107(3):987-92.

    7. Drummond MJ, Dreyer HC, Pennings B, Fry CS, Dhanani S, Dillon EL, et al. Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging. Journal of applied physiology. 2008;104(5):1452- 61.

    8. Dideriksen KJ, Reitelseder S, Petersen SG, Hjort M, Helmark IC, Kjaer M, et al. Stimulation of muscle protein synthesis by whey and caseinate ingestion after resistance exercise in elderly individuals. Scandinavian journal of medicine & science in sports. 2011;21(6):e372-83.

    9. Fujita S, Dreyer HC, Drummond MJ, Glynn EL, Cadenas JG, Yoshizawa F, et al. Nutrient signalling in the regulation of human muscle protein synthesis. The Journal of physiology. 2007;582(Pt 2):813-23.

    10. Churchward-Venne TA, Burd NA, Mitchell CJ, West DW, Philp A, Marcotte GR, et al. Supplementation of a suboptimal protein dose with leucine or essential amino acids: effects on myofibrillar protein synthesis at rest and following resistance exercise in men. The Journal of physiology. 2012;590(Pt 11):2751-65.

    11. Pedersen BK, Hoffman-Goetz L. Exercise and the immune system: regulation, integration, and adaptation. Physiological reviews. 2000;80(3):1055-81.

    12. McCarthy DA, Dale MM. The leucocytosis of exercise. A review and model. Sports Med. 1988;6(6):333-63.

    13. Brines R, Hoffman-Goetz L, Pedersen BK. Can you exercise to make your immune system fitter? Immunol Today. 1996;17(6):252-4.

    14. Smith JA, Telford RD, Mason IB, Weidemann MJ. Exercise, training and neutrophil microbicidal activity. Int J Sports Med. 1990;11(3):179-87.

    15. Mackinnon LT, Hooper S. Mucosal (secretory) immune system responses to exercise of varying intensity and during overtraining. Int J Sports Med. 1994;15 Suppl 3:S179-83.

    16. Housh TJ, Johnson GO, Housh DJ, Evans SL, Tharp GD. The effect of exercise at various temperatures on salivary levels of immunoglobulin A. Int J Sports Med. 1991;12(5):498-500.

    17. McDowell SL, Hughes RA, Hughes RJ, Housh DJ, Housh TJ, Johnson GO. The effect of exhaustive exercise on salivary immunoglobulin A. J Sports Med Phys Fitness. 1992;32(4):412-5.

    18. Beaufrere B eaI. The ‘fast’ and ‘slow’ protein concept. In: Furst P, Young V, (ed.), editors. Proteins, Peptides and Amino Acids in Enteral Nutrition,. 3. Basel, Germany: Karger; 2000. p. 121-33. www.enterahealth.com/immunolin ENT279A118 9

    19. Calbet JA, Holst JJ. Gastric emptying, gastric secretion and enterogastrone response after administration of milk proteins or their peptide hydrolysates in humans. European journal of nutrition. 2004;43(3):127-39.

    20. Koopman R, Crombach N, Gijsen AP, Walrand S, Fauquant J, Kies AK, et al. Ingestion of a protein hydrolysate is accompanied by an accelerated in vivo digestion and absorption rate when compared with its intact protein. The American journal of clinical nutrition. 2009;90(1):106-15.

    21. Bounous G. Whey protein concentrate (WPC) and glutathione modulation in cancer treatment. Anticancer Res. 2000;20(6C):4785-92.

    22. Kennedy RS, Konok GP, Bounous G, Baruchel S, Lee TD. The use of a whey protein concentrate in the treatment of patients with metastatic carcinoma: a phase I-II clinical study. Anticancer Res. 1995;15(6B):2643-9.

    23. Hakkak R, Korourian S, Shelnutt SR, Lensing S, Ronis MJ, Badger TM. Diets containing whey proteins or soy protein isolate protect against 7,12-dimethylbenz(a)anthracene-induced mammary tumors in female rats. Cancer Epidemiol Biomarkers Prev. 2000;9(1):113-7.

    24. Lands LC, Grey VL, Smountas AA. Effect of supplementation with a cysteine donor on muscular performance. Journal of applied physiology. 1999;87(4):1381-5.

    25. Hofman Z, Smeets R, Verlaan G, Lugt R, Verstappen PA. The effect of bovine colostrum supplementation on exercise performance in elite field hockey players. Int J Sport Nutr Exerc Metab. 2002;12(4):461-9.

    26. Antonio J, Sanders MS, Van Gammeren D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition. 2001;17(3):243-7.

     

    27. Godhia ML, N. P. Colostrum – Its Composition, Benefits As A Nutraceutical : A Review. Current Research in Nutrition and Food Science. 2013;1(1):37-47.

    28. Uruakpa F, Ismond M, Akobundu E. Colostrum and its benefits: a review. Nutrition research. 2002;22:755-67.

    29. Hurley WL, Theil PK. Perspectives on immunoglobulins in colostrum and milk. Nutrients. 2011;3(4):442-74.

    30. Walker A. Breast milk as the gold standard for protective nutrients. The Journal of pediatrics. 2010;156(2 Suppl):S3-7.

    31. Horgan A, Maas KJ, Henderson A, Detzel CJ, Weaver EM. Serum-derived bovine immunoglobulin/protein isolate binds to pathogen-associated molecular patterns. FASEB journal. 2014;128: Suppl No. 1; 836.6.

    32. Weaver EM, Klein GL, DeVries BK, Maas KJ, Shaw AL. Endotoxin Neutralization activity (ENA) of bovine plasma and bovine Immunoglobulin (IgG)-rich fractions as compared to human plasma. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013;27:1079.58.

    33. Tomita GM, Todhunter DA, Hogan JS, Smith KL. Antigenic crossreactivity and lipopolysaccharide neutralization properties of bovine immunoglobulin G. Journal of dairy science. 1995;78(12):2745-52.

    34. Ostrowski K, Rohde T, Asp S, Schjerling P, Pedersen BK. Pro- and anti-inflammatory cytokine balance in strenuous exercise in humans. The Journal of physiology. 1999;515 ( Pt 1):287-91.

    35. Ostrowski K, Rohde T, Zacho M, Asp S, Pedersen BK. Evidence that interleukin-6 is produced in human skeletal muscle during prolonged running. The Journal of physiology. 1998;508 ( Pt 3):949-53.

    36. Bosenberg AT, Brock-Utne JG, Gaffin SL, Wells MT, Blake GT. Strenuous exercise causes systemic endotoxemia. Journal of applied physiology. 1988;65(1):106-8.

    37. Brock-Utne JG, Gaffin SL, Wells MT, Gathiram P, Sohar E, James MF, et al. Endotoxaemia in exhausted runners after a long-distance race. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde. 1988;73(9):533-6.

    38. Fritscher-Ravens A, Schuppan D, Ellrichmann M, Schoch S, Rocken C, Brasch J, et al. Confocal endomicroscopy shows food-associated changes in the intestinal mucosa of patients with irritable bowel syndrome. Gastroenterology. 2014;147(5):1012-20 e4.

    39. Detzel CJ, Horgan A, Henderson AL, Petschow BW, Warner CD, Maas KJ, et al. Bovine immunoglobulin/protein isolate binds pro-inflammatory bacterial compounds and prevents immune activation in an intestinal co-culture model. PloS one. 2015;10(4):e0120278. www.enterahealth.com/immunolin ENT279A118 10

    40. Kuchibhatla R, Petschow BW, Odle J, Weaver EM. Nutritional Impact of Dietary Plasma Proteins in Animals Undergoing Experimental Challenge and Implications for Patients with Inflammatory Bowel Disorders: A Meta-analysis. Adv Nutr. 2015;6(5):541-51.

    41. Torrallardona D. Spray dried animal plasma as an alternative to antibiotics in weanling pigs – A review. Asian-Australasian J Anim Sci. 2010;23((1)):131-48.

    42. Coffey RD, Cromwell GL. Use of spray-dried animal plasma in diets for weanling pigs. Pig News and Information. 2001;22((2)):39N-48N.

    43. Perez-Bosque A, Miro L, Maijo M, Polo J, Campbell J, Russell L, et al. Dietary intervention with serum-derived bovine immunoglobulins protects barrier function in a mouse model of colitis. American journal of physiology Gastrointestinal and liver physiology. 2015;308(12):G1012-8.

    44. Henderson AL, Brand MW, Darling RJ, Maas KJ, Detzel CJ, Hostetter J, et al. Attenuation of Colitis by Serum-Derived Bovine Immunoglobulin/Protein Isolate in a Defined Microbiota Mouse Model. Digestive diseases and sciences. 2015;60(11):3293-303.

    45. Wilson D, Evans MD, Weaver E, Shaw AL, Klein GL. Evaluation of Serum-Derived Bovine Immunoglobulin Protein Isolate in Subjects with Diarrhea-Predominant Irritable Bowel Syndrome. Clinical Medicine Insights: Gastroenterology. 2013;6:49-60.

    46. Asmuth DM, Ma ZM, Albanese A, Sandler NG, Devaraj S, Knight TH, et al. Oral Serum-Derived Bovine Immunoglobulin Improves Duodenal Immune Reconstitution and Absorption Function in Patients with HIV Enteropathy. Aids. 2013;27:2207-17.

    47. Asmuth DM, Somsouk M, Hunt P, Ma ZM, Miller CL, X.D., Hinkle J, et al. Serum-Derived Bovine Immunoglobulin Protein Isolate Increases Peripheral and Mucosal CD4+ T-cell counts in Patients with HIV Enteropathy. 8th IAS Conference on HIV Pathogenesis, Treatment and Prevention (AIDS 2015); MOAA02; Vancouver, Canada 19-22 July: http://www.ias2015.org/WebContent/File/IAS_2015__MED2.pdf; 2015.

    48. Lembcke JL, Peerson JM, Brown KH. Acceptability, safety, and digestibility of spray-dried bovine serum added to diets of recovering malnourished children. Journal of pediatric gastroenterology and nutrition. 1997;25(4):381-4.

    49. Begin F, Santizo MC, Peerson JM, Torun B, Brown KH. Effects of bovine serum concentrate, with or without supplemental micronutrients, on the growth, morbidity, and micronutrient status of young children in a low-income, peri-urban Guatemalan community. European journal of clinical nutrition. 2008;62(1):39-50.

    50. Perez-Bosque A, Miro L, Maijo M, Polo J, Campbell JM, Russell L, et al. Oral Serum-Derived Bovine Immunoglobulin/ Protein Isolate Has Immunomodulatory Effects on the Colon of Mice that Spontaneously Develop Colitis. PloS one. 2016;11(5):e0154823.

    51. Bosi P, Casini L, Finamore A, Cremokolini C, Merialdi G, Trevisi P, et al. Spray-dried plasma improves growth performance and reduces inflammatory status of weaned pigs challenged with enterotoxigenic Escherichia coli K88. Journal of animal science. 2004;82(6):1764-72.

    52. Maijo M, Miro L, Polo J, Campbell J, Russell L, Crenshaw J, et al. Dietary plasma proteins attenuate the innate immunity response in a mouse model of acute lung injury. The British journal of nutrition. 2012;107(6):867-75.

    53. Maijo M, Miro L, Polo J, Campbell J, Russell L, Crenshaw J, et al. Dietary plasma proteins modulate the adaptive immune response in mice with acute lung inflammation. The Journal of nutrition. 2012;142(2):264-70.

    54. Kiyono H, Fukuyama S. NALT- versus Peyer’s-patch-mediated mucosal immunity. Nature reviews Immunology. 2004;4(9):699-710. 55. Anderson NL, Anderson NG. The human plasma proteome: history, character, and diagnostic prospects. Mol Cell Proteomics. 2002;1(11):845-67.

    Statements made on this website have not been evaluated by the FDA and are for informational purposes only. They are not intended to diagnose, treat or cure any illness or disease. Consult your physician, naturopath, chiropractor or holistic doctor if you have any questions related to how Extreme Immunity can work as part of your overall health plan. Extreme Immunity's natural dietary supplement for the immune system is manufactured and packaged under the strictest quality control measures in the United States.